TIMOUMI, Ramzi; AMANIAMPONG, Prince Nana; LE POSTOLLEC, Aurelie; DOBRIJEVIC, Michel; RIOLAND, Guillaume; GREGOIRE, Brian; POINOT, Pauline; GEFFROY-RODIER, Claude

doi:10.1016/j.ultsonch.2024.106775

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TIMOUMI, Ramzi
Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]

AMANIAMPONG, Prince Nana
Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]

LE POSTOLLEC, Aurelie
Laboratoire d'Astrophysique de Bordeaux [Pessac] [LAB]

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Article de revue

Ce document a été publié dans

Ultrasonics Sonochemistry. 2024-02, vol. 103, p. 106775

Elsevier

Résumé en anglais

The design of innovative therapeutic strategies enabling the selective destruction of tumor cells while sparing healthy tissues remains highly challenging in cancer therapy. Here, we show that the combination of two targeted therapies, including bevacizumab (Bev), and a beta-glucuronidase-responsive albumin-binding prodrug of monomethyl auristatin E (MMAE), is efficient for the treatment of colorectal cancer implanted in mice. This combined therapy produces a therapeutic activity superior to that of the association of FOLFOX and Bev currently used to treat patients with this pathology. The increased anticancer efficacy is due to either a synergistic or an additive effect between Bev and MMAE selectively released from the glucuronide prodrug in the tumor microenvironment. Since numerous drug delivery systems such as antibody-drug conjugates employ MMAE as a cytotoxic payload, this finding may be of great interest for improving their therapeutic index by combining them with Bev, particularly for the therapy of colorectal cancer.< Réduire

Mots clés en anglais

UAE Meteorite

Amino acids

Nucleobases

Peptides

Ultrasound frequency

DOI

http://dx.doi.org/10.1016/j.ultsonch.2024.106775

Project ANR

Integrative analytical unit for the study of emergent catalytic systems - ANR-22-EXOR-0014

Origine

Importé de hal

Unités de recherche

Laboratoire d'Astrophysique de Bordeaux (LAB) - UMR 5804