Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents
MNASRI, Walid
Interfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)]
Unité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux
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Interfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)]
Unité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux
MNASRI, Walid
Interfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)]
Unité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux
Interfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)]
Unité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux
SANDRE, Olivier
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Journal of Interdisciplinary Nanomedicine. 2019, vol. 4, n° 1, p. 4-23
Résumé en anglais
The structural, microstructural, and magnetic properties of ~5‐nm‐sized Co0.6Zn0.4Fe2−xGdxO4 nanoparticles were investigated in order to evaluate their capability to enhance the magnetic resonance imaging contrast as high ...Lire la suite >
The structural, microstructural, and magnetic properties of ~5‐nm‐sized Co0.6Zn0.4Fe2−xGdxO4 nanoparticles were investigated in order to evaluate their capability to enhance the magnetic resonance imaging contrast as high magnetization agents. A focus was made on the solubility of Gd3+ cations within the spinel lattice. By coupling X‐ray diffraction to X‐ray fluorescence spectroscopy, we demonstrated that only a limited fraction of Gd3+ can substitute Fe3+ ions into the whole crystal structure and does not exceed 6 at.‐%. At this concentration, the room temperature (27°C) saturation magnetizations of the prepared superparamagnetic nanocrystals were found to be close to 80 emu g−1. Coating these nanoparticles with hydrophilic dopamine ligands leads to the formation of ~50‐nm‐sized clusters in water. As a consequence, relatively high r2/r1 ratios of transverse to longitudinal proton relaxivities and high r2 values were measured in the resulting colloids at physiological temperature (37°C) for an applied magnetic field of 1.41 T: 33 and 188 mM−1 sec−1, respectively, for the richest system in gadolinium. Moreover, after incubation with healthy human model cells (fibroblasts) at doses as high as 10 μg mL−1, they induce neither cellular death nor acute cellular damage making the engineered probes particularly valuable for negative magnetic resonance imaging contrasting.< Réduire
Mots clés en anglais
Gadolinium-substituted cobalt-zinc ferrite
MRI negative contrast agents
nanoparticles
polyol process
Project ANR
USPC - ANR-11-IDEX-0005-02/11-IDEX-0005
Science and Engineering for Advanced Materials and devices - ANR-10-LABX-0096
Science and Engineering for Advanced Materials and devices - ANR-10-LABX-0096
Origine
Importé de halUnités de recherche