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Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents

dc.rights.licenseopen
hal.structure.identifierInterfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)]
hal.structure.identifierUnité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux
dc.contributor.authorMNASRI, Walid
hal.structure.identifierUnité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux
dc.contributor.authorBENTAHAR, Lotfi
hal.structure.identifierInterfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)]
dc.contributor.authorNOWAK, Sophie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierEquipe de recherche sur les relations matrice extracellulaire-cellules [ERRMECe]
dc.contributor.authorBOISSIÈRE, Michel
hal.structure.identifierInterfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)]
dc.contributor.authorAMMAR, Souad
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2019
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19890
dc.description.abstractEnThe structural, microstructural, and magnetic properties of ~5‐nm‐sized Co0.6Zn0.4Fe2−xGdxO4 nanoparticles were investigated in order to evaluate their capability to enhance the magnetic resonance imaging contrast as high magnetization agents. A focus was made on the solubility of Gd3+ cations within the spinel lattice. By coupling X‐ray diffraction to X‐ray fluorescence spectroscopy, we demonstrated that only a limited fraction of Gd3+ can substitute Fe3+ ions into the whole crystal structure and does not exceed 6 at.‐%. At this concentration, the room temperature (27°C) saturation magnetizations of the prepared superparamagnetic nanocrystals were found to be close to 80 emu g−1. Coating these nanoparticles with hydrophilic dopamine ligands leads to the formation of ~50‐nm‐sized clusters in water. As a consequence, relatively high r2/r1 ratios of transverse to longitudinal proton relaxivities and high r2 values were measured in the resulting colloids at physiological temperature (37°C) for an applied magnetic field of 1.41 T: 33 and 188 mM−1 sec−1, respectively, for the richest system in gadolinium. Moreover, after incubation with healthy human model cells (fibroblasts) at doses as high as 10 μg mL−1, they induce neither cellular death nor acute cellular damage making the engineered probes particularly valuable for negative magnetic resonance imaging contrasting.
dc.description.sponsorshipUSPC - ANR-11-IDEX-0005-02/11-IDEX-0005
dc.description.sponsorshipScience and Engineering for Advanced Materials and devices - ANR-10-LABX-0096
dc.language.isoen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.subject.enGadolinium-substituted cobalt-zinc ferrite
dc.subject.enMRI negative contrast agents
dc.subject.ennanoparticles
dc.subject.enpolyol process
dc.title.enEvaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents
dc.typeArticle de revue
dc.identifier.doi10.1002/jin2.53
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Chimie inorganique
bordeaux.journalJournal of Interdisciplinary Nanomedicine
bordeaux.page4-23
bordeaux.volume4
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue1
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02023187
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02023187v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Interdisciplinary%20Nanomedicine&rft.date=2019&rft.volume=4&rft.issue=1&rft.spage=4-23&rft.epage=4-23&rft.au=MNASRI,%20Walid&BENTAHAR,%20Lotfi&NOWAK,%20Sophie&SANDRE,%20Olivier&BOISSI%C3%88RE,%20Michel&rft.genre=article


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