Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents
dc.rights.license | open | |
hal.structure.identifier | Interfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)] | |
hal.structure.identifier | Unité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux | |
dc.contributor.author | MNASRI, Walid | |
hal.structure.identifier | Unité de Recherche UR11ES30 de Synthèse et Structures de Nanomatériaux | |
dc.contributor.author | BENTAHAR, Lotfi | |
hal.structure.identifier | Interfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)] | |
dc.contributor.author | NOWAK, Sophie | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | SANDRE, Olivier | |
hal.structure.identifier | Equipe de recherche sur les relations matrice extracellulaire-cellules [ERRMECe] | |
dc.contributor.author | BOISSIÈRE, Michel | |
hal.structure.identifier | Interfaces, Traitements, Organisation et Dynamique des Systèmes [ITODYS (UMR_7086)] | |
dc.contributor.author | AMMAR, Souad | |
dc.date.accessioned | 2020 | |
dc.date.available | 2020 | |
dc.date.issued | 2019 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/19890 | |
dc.description.abstractEn | The structural, microstructural, and magnetic properties of ~5‐nm‐sized Co0.6Zn0.4Fe2−xGdxO4 nanoparticles were investigated in order to evaluate their capability to enhance the magnetic resonance imaging contrast as high magnetization agents. A focus was made on the solubility of Gd3+ cations within the spinel lattice. By coupling X‐ray diffraction to X‐ray fluorescence spectroscopy, we demonstrated that only a limited fraction of Gd3+ can substitute Fe3+ ions into the whole crystal structure and does not exceed 6 at.‐%. At this concentration, the room temperature (27°C) saturation magnetizations of the prepared superparamagnetic nanocrystals were found to be close to 80 emu g−1. Coating these nanoparticles with hydrophilic dopamine ligands leads to the formation of ~50‐nm‐sized clusters in water. As a consequence, relatively high r2/r1 ratios of transverse to longitudinal proton relaxivities and high r2 values were measured in the resulting colloids at physiological temperature (37°C) for an applied magnetic field of 1.41 T: 33 and 188 mM−1 sec−1, respectively, for the richest system in gadolinium. Moreover, after incubation with healthy human model cells (fibroblasts) at doses as high as 10 μg mL−1, they induce neither cellular death nor acute cellular damage making the engineered probes particularly valuable for negative magnetic resonance imaging contrasting. | |
dc.description.sponsorship | USPC - ANR-11-IDEX-0005-02/11-IDEX-0005 | |
dc.description.sponsorship | Science and Engineering for Advanced Materials and devices - ANR-10-LABX-0096 | |
dc.language.iso | en | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/ | |
dc.subject.en | Gadolinium-substituted cobalt-zinc ferrite | |
dc.subject.en | MRI negative contrast agents | |
dc.subject.en | nanoparticles | |
dc.subject.en | polyol process | |
dc.title.en | Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1002/jin2.53 | |
dc.subject.hal | Chimie/Matériaux | |
dc.subject.hal | Chimie/Chimie inorganique | |
bordeaux.journal | Journal of Interdisciplinary Nanomedicine | |
bordeaux.page | 4-23 | |
bordeaux.volume | 4 | |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
bordeaux.issue | 1 | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-02023187 | |
hal.version | 1 | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-02023187v1 | |
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