BEAUTÉ, Louis; MCCLENAGHAN, Nathan; LECOMMANDOUX, Sebastien

doi:10.1016/j.addr.2018.12.010

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BEAUTÉ, Louis
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Institut des Sciences Moléculaires [ISM]

MCCLENAGHAN, Nathan
Institut des Sciences Moléculaires [ISM]

LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Langue

Article de revue

Ce document a été publié dans

Advanced Drug Delivery Reviews. 2019, vol. 138, p. 148-166

Elsevier

Résumé en anglais

The use of nanotechnology to improve treatment efficacy and reduce side effects is central to nanomedicine. In this context, stimuli-responsive drug delivery systems (DDS) such as chemical/physical gels or nanoparticles such as polymersomes, micelles or nanogels are particularly promising and are the focus of this review. Several stimuli have been considered but light as an exogenous trigger presents many advantages that are pertinent for clinical applications such as high spatial and temporal control and low cost. Underlying mechanisms required for the release of therapeutic agents in vitro and in vivo range from the molecular scale, namely photoisomerization, hydrophobicity photoswitching, photocleavage or heat generation via nanoheaters, through to the macromolecular scale. As well as these approaches, DDS destabilization, DDS permeation pore unblocking and formation are discussed.< Réduire

Mots clés en anglais

Drug-delivery Light- responsive Polymers Nanomedicine Gels Nanoparticles

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19852

DOI

http://dx.doi.org/10.1016/j.addr.2018.12.010

Project ANR

Développement de cellule synthétique comme micro-réacteur pour l'étude de l'activité enzymatique des NO-synthases et la compréhension de leur fonctionnement en conditions physiologiques - ANR-14-CE16-0015

Origine

Importé de hal

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629