Photo-triggered polymer nanomedicines: From molecular mechanisms to therapeutic applications
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | BEAUTÉ, Louis | |
| hal.structure.identifier | Institut des Sciences Moléculaires [ISM] | |
| dc.contributor.author | MCCLENAGHAN, Nathan | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0169-409X | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/19852 | |
| dc.description.abstractEn | The use of nanotechnology to improve treatment efficacy and reduce side effects is central to nanomedicine. In this context, stimuli-responsive drug delivery systems (DDS) such as chemical/physical gels or nanoparticles such as polymersomes, micelles or nanogels are particularly promising and are the focus of this review. Several stimuli have been considered but light as an exogenous trigger presents many advantages that are pertinent for clinical applications such as high spatial and temporal control and low cost. Underlying mechanisms required for the release of therapeutic agents in vitro and in vivo range from the molecular scale, namely photoisomerization, hydrophobicity photoswitching, photocleavage or heat generation via nanoheaters, through to the macromolecular scale. As well as these approaches, DDS destabilization, DDS permeation pore unblocking and formation are discussed. | |
| dc.description.sponsorship | Développement de cellule synthétique comme micro-réacteur pour l'étude de l'activité enzymatique des NO-synthases et la compréhension de leur fonctionnement en conditions physiologiques - ANR-14-CE16-0015 | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.subject.en | Drug-delivery Light- responsive Polymers Nanomedicine Gels Nanoparticles | |
| dc.title.en | Photo-triggered polymer nanomedicines: From molecular mechanisms to therapeutic applications | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.addr.2018.12.010 | |
| dc.subject.hal | Chimie/Polymères | |
| dc.subject.hal | Chimie/Matériaux | |
| dc.subject.hal | Physique [physics]/Physique [physics]/Optique [physics.optics] | |
| bordeaux.journal | Advanced Drug Delivery Reviews | |
| bordeaux.page | 148-166 | |
| bordeaux.volume | 138 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02098559 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02098559v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Advanced%20Drug%20Delivery%20Reviews&rft.date=2019&rft.volume=138&rft.spage=148-166&rft.epage=148-166&rft.eissn=0169-409X&rft.issn=0169-409X&rft.au=BEAUT%C3%89,%20Louis&MCCLENAGHAN,%20Nathan&LECOMMANDOUX,%20Sebastien&rft.genre=article |
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