LE FER, Gaëlle; PORTES, Delphine; GOUDOUNET, Guillaume; GUIGNER, Jean-Michel; GARANGER, Elisabeth; LECOMMANDOUX, Sebastien

doi:10.1039/C7OB01945A

Metadatos

Licencia de uso del documento

LE FER, Gaëlle
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]

PORTES, Delphine
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]

GOUDOUNET, Guillaume
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]

Idioma

Article de revue

Este ítem está publicado en

Organic and Biomolecular Chemistry. 2017, vol. 15, n° 47, p. 10095-10104

Royal Society of Chemistry

Resumen en inglés

The precision synthesis and self-assembly of amphiphilic copolypeptides containing a recombinant elastin-like polypeptide (ELP) block used as a macroinitiator for the ring opening polymerization (ROP) of γ-benzyl-L-glutamate (γ-BLG NCA) are herein presented. The molecular weight of the resulting PBLG-b-ELP block copolypeptides was precisely controlled without the use of complex initiator or demanding experimental setup. Diblock copolypeptides were obtained with an excellent control of the polymerization highlighted by the dispersity below 1.04. These amphiphilic hybrid synthetic/recombinant copolypeptides were self-assembled in water and the nanoparticles obtained were characterized by a combination of dynamic light scattering and electron microscopy. A variety of morphologies, namely polymersomes, inter-connected worm-like micelles and spherical micelles, were evidenced depending on the hydrophilic ratio of the diblocks as well as the self-assembly procedure.< Leer menos

Palabras clave en inglés

Elastin-like polypeptides

poly(γ-benzyl-L-glutamate)

amphiphilic block copolymers

microfluidics

self-assembly

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19851

DOI

http://dx.doi.org/10.1039/C7OB01945A

Proyecto ANR

Développement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis - ANR-15-CE07-0002

Orígen

Importado de Hal

Centros de investigación

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629