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Design and self-assembly of PBLG-b-ELP hybrid diblock copolymers based on synthetic and elastin-like polypeptides

dc.rights.licenseopen
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorLE FER, Gaëlle
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorPORTES, Delphine
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorGOUDOUNET, Guillaume
hal.structure.identifierInstitut de minéralogie, de physique des matériaux et de cosmochimie [IMPMC]
dc.contributor.authorGUIGNER, Jean-Michel
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn1477-0520
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19851
dc.description.abstractEnThe precision synthesis and self-assembly of amphiphilic copolypeptides containing a recombinant elastin-like polypeptide (ELP) block used as a macroinitiator for the ring opening polymerization (ROP) of γ-benzyl-L-glutamate (γ-BLG NCA) are herein presented. The molecular weight of the resulting PBLG-b-ELP block copolypeptides was precisely controlled without the use of complex initiator or demanding experimental setup. Diblock copolypeptides were obtained with an excellent control of the polymerization highlighted by the dispersity below 1.04. These amphiphilic hybrid synthetic/recombinant copolypeptides were self-assembled in water and the nanoparticles obtained were characterized by a combination of dynamic light scattering and electron microscopy. A variety of morphologies, namely polymersomes, inter-connected worm-like micelles and spherical micelles, were evidenced depending on the hydrophilic ratio of the diblocks as well as the self-assembly procedure.
dc.description.sponsorshipDéveloppement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis - ANR-15-CE07-0002
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enElastin-like polypeptides
dc.subject.enpoly(γ-benzyl-L-glutamate)
dc.subject.enamphiphilic block copolymers
dc.subject.enmicrofluidics
dc.subject.enself-assembly
dc.title.enDesign and self-assembly of PBLG-b-ELP hybrid diblock copolymers based on synthetic and elastin-like polypeptides
dc.typeArticle de revue
dc.identifier.doi10.1039/C7OB01945A
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halSciences du Vivant [q-bio]/Biotechnologies
bordeaux.journalOrganic and Biomolecular Chemistry
bordeaux.page10095-10104
bordeaux.volume15
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue47
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01660141
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01660141v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Organic%20and%20Biomolecular%20Chemistry&rft.date=2017&rft.volume=15&rft.issue=47&rft.spage=10095-10104&rft.epage=10095-10104&rft.eissn=1477-0520&rft.issn=1477-0520&rft.au=LE%20FER,%20Ga%C3%ABlle&PORTES,%20Delphine&GOUDOUNET,%20Guillaume&GUIGNER,%20Jean-Michel&GARANGER,%20Elisabeth&rft.genre=article


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