XIAO, Ye; CHINOY, Zoeisha; PÉCASTAINGS, Gilles; BATHANY, Katell; GARANGER, Elisabeth; LECOMMANDOUX, Sebastien

doi:10.1021/acs.biomac.9b01058

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XIAO, Ye
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

CHINOY, Zoeisha
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

PÉCASTAINGS, Gilles
Laboratoire de Chimie des Polymères Organiques [LCPO]

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Article de revue

Ce document a été publié dans

Biomacromolecules. 2020, vol. 21, n° 1, p. 114-125

American Chemical Society

Résumé en anglais

The advantageous biological properties of polysaccharides and precise stimuli-responsiveness of elastin-like polypeptides (ELPs) are of great interest for the design of polysaccharide and polypeptide-based amphiphilic block copolymers for biomedical applications. Herein, we report the synthesis and characterization of a series of polysaccharide-block-ELP copolymers, containing two biocompatible and biodegradable blocks coupled via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The resulting bioconjugates are capable of self-assembling into well-defined nanoparticles in aqueous solution upon raising the solution temperature above a specific transition temperature (Tt) – a characteristic of the ELP moiety. To the best of our knowledge, this is the first study where polysaccharides were combined with a stimuli-responsive ELP for the preparation of thermo-sensitive self-assemblies, providing insight into novel pathways for designing bioinspired stimuli-responsive self-assemblies for biomedical applications.< Réduire

Mots clés en anglais

Elastin-like polypeptides

Block copolymers

Polysaccharides

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19713

DOI

http://dx.doi.org/10.1021/acs.biomac.9b01058

Project ANR

Développement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis - ANR-15-CE07-0002

Origine

Importé de hal

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629