Design of polysaccharide-b-elastin like polypeptide bioconjugates and their thermoresponsive self-assembly
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | XIAO, Ye | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | CHINOY, Zoeisha | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | PÉCASTAINGS, Gilles | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BATHANY, Katell | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1525-7797 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/19713 | |
| dc.description.abstractEn | The advantageous biological properties of polysaccharides and precise stimuli-responsiveness of elastin-like polypeptides (ELPs) are of great interest for the design of polysaccharide and polypeptide-based amphiphilic block copolymers for biomedical applications. Herein, we report the synthesis and characterization of a series of polysaccharide-block-ELP copolymers, containing two biocompatible and biodegradable blocks coupled via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The resulting bioconjugates are capable of self-assembling into well-defined nanoparticles in aqueous solution upon raising the solution temperature above a specific transition temperature (Tt) – a characteristic of the ELP moiety. To the best of our knowledge, this is the first study where polysaccharides were combined with a stimuli-responsive ELP for the preparation of thermo-sensitive self-assemblies, providing insight into novel pathways for designing bioinspired stimuli-responsive self-assemblies for biomedical applications. | |
| dc.description.sponsorship | Développement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis - ANR-15-CE07-0002 | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.subject.en | Elastin-like polypeptides | |
| dc.subject.en | Block copolymers | |
| dc.subject.en | Polysaccharides | |
| dc.title.en | Design of polysaccharide-b-elastin like polypeptide bioconjugates and their thermoresponsive self-assembly | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/acs.biomac.9b01058 | |
| dc.subject.hal | Chimie/Polymères | |
| dc.subject.hal | Chimie/Matériaux | |
| dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | |
| bordeaux.journal | Biomacromolecules | |
| bordeaux.page | 114-125 | |
| bordeaux.volume | 21 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 1 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02299856 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02299856v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2020&rft.volume=21&rft.issue=1&rft.spage=114-125&rft.epage=114-125&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=XIAO,%20Ye&CHINOY,%20Zoeisha&P%C3%89CASTAINGS,%20Gilles&BATHANY,%20Katell&GARANGER,%20Elisabeth&rft.genre=article |
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