NGUYEN, Michel; FERJI, Khalid; LECOMMANDOUX, Sebastien; BONDUELLE, Colin

doi:10.3390/polym12061357

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NGUYEN, Michel
Laboratoire de chimie de coordination [LCC]

FERJI, Khalid
Laboratoire de Chimie Physique Macromoléculaire [LCPM]

LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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2020, vol. 12, n° 6, p. 1357

MDPI

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Nucleobase-containing polymers are an emerging class of building blocks for the self-assembly of nanoobjects with promising applications in nanomedicine and biology. Here we present a macromolecular engineering approach to design nucleobase-containing polypeptide polymers incorporating thymine that further self-assemble in nanomaterials. Diblock and triblock copolypeptide polymers were prepared using sequential ring-opening polymerization of γ-Benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and γ-Propargyl-l-glutamate N-carboxyanhydride (PLG-NCA), followed by an efficient copper(I)-catalyzed azide alkyne cycloaddition (CuAAc) functionalization with thymidine monophosphate. Resulting amphiphilic copolymers were able to spontaneously form nanoobjects in aqueous solutions avoiding a pre-solubilization step with an organic solvent. Upon self-assembly, light scattering measurements and transmission electron microscopy (TEM) revealed the impact of the architecture (diblock versus triblock) on the morphology of the resulted nanoassemblies. Interestingly, the nucleobase-containing nanoobjects displayed free thymine units in the shell that were found available for further DNA-binding.< Réduire

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sequential ring-opening polymerization

amphiphilic polypeptide

nucleobase

spontaneous self-assembly

DNA binding

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Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly

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