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Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly

dc.rights.licenseopen
hal.structure.identifierLaboratoire de chimie de coordination [LCC]
dc.contributor.authorNGUYEN, Michel
hal.structure.identifierLaboratoire de Chimie Physique Macromoléculaire [LCPM]
dc.contributor.authorFERJI, Khalid
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de chimie de coordination [LCC]
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBONDUELLE, Colin
IDREF: 134527046
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2020
dc.identifier.issn2073-4360
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19662
dc.description.abstractEnNucleobase-containing polymers are an emerging class of building blocks for the self-assembly of nanoobjects with promising applications in nanomedicine and biology. Here we present a macromolecular engineering approach to design nucleobase-containing polypeptide polymers incorporating thymine that further self-assemble in nanomaterials. Diblock and triblock copolypeptide polymers were prepared using sequential ring-opening polymerization of γ-Benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and γ-Propargyl-l-glutamate N-carboxyanhydride (PLG-NCA), followed by an efficient copper(I)-catalyzed azide alkyne cycloaddition (CuAAc) functionalization with thymidine monophosphate. Resulting amphiphilic copolymers were able to spontaneously form nanoobjects in aqueous solutions avoiding a pre-solubilization step with an organic solvent. Upon self-assembly, light scattering measurements and transmission electron microscopy (TEM) revealed the impact of the architecture (diblock versus triblock) on the morphology of the resulted nanoassemblies. Interestingly, the nucleobase-containing nanoobjects displayed free thymine units in the shell that were found available for further DNA-binding.
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.ensequential ring-opening polymerization
dc.subject.enamphiphilic polypeptide
dc.subject.ennucleobase
dc.subject.enspontaneous self-assembly
dc.subject.enDNA binding
dc.title.enAmphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly
dc.typeArticle de revue
dc.identifier.doi10.3390/polym12061357
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire
bordeaux.page1357
bordeaux.volume12
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue6
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02876032
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02876032v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2020&rft.volume=12&rft.issue=6&rft.spage=1357&rft.epage=1357&rft.eissn=2073-4360&rft.issn=2073-4360&rft.au=NGUYEN,%20Michel&FERJI,%20Khalid&LECOMMANDOUX,%20Sebastien&BONDUELLE,%20Colin&rft.genre=article


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