DERIEPPE, Marc; DENIS DE SENNEVILLE, Baudouin; KUIJF, Hugo; BOS, Clemens; MOONEN, Chrit

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

DERIEPPE, Marc
University Medical Center [Utrecht] [UMCU]

DENIS DE SENNEVILLE, Baudouin
University Medical Center [Utrecht] [UMCU]
Institut de Mathématiques de Bordeaux [IMB]

KUIJF, Hugo
Image sciences institute - University of Utrecht [ISI]

Langue

Communication dans un congrès

Ce document a été publié dans

IEEE International Symposium on Biomedical Imaging (ISBI), 2014-04-16, Beijing.

Résumé en anglais

Local drug delivery in oncology aims at depositing high doses of anticancer agents while limiting their toxic side effects. Biological barriers, such as cell plasma membranes, hinder their delivery and requires strategies to address this challenge. Previously [1], we demonstrated the feasibility to monitor in real-time, with dynamic fluorescence microscopy, the in-tracellular delivery of a hydrophilic model drug mediated by ultrasound (US), and to quantify the pharmacokinetic parameters derived from a two-compartment model. We evaluate here the impact of the photobleaching (PB) effect experimentally , and compute the PB-corrected uptake kinetics.< Réduire

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Cell Tracking for Assessment of In-Vitro Uptake Kinetics in Ultrasound-Mediated Drug Delivery using Fibered Confocal Fluorescence Microscopy

Langue

Ce document a été publié dans

Résumé en anglais

URI

Origine

Unités de recherche