Cell Tracking for Assessment of In-Vitro Uptake Kinetics in Ultrasound-Mediated Drug Delivery using Fibered Confocal Fluorescence Microscopy
DENIS DE SENNEVILLE, Baudouin
University Medical Center [Utrecht] [UMCU]
Institut de Mathématiques de Bordeaux [IMB]
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University Medical Center [Utrecht] [UMCU]
Institut de Mathématiques de Bordeaux [IMB]
DENIS DE SENNEVILLE, Baudouin
University Medical Center [Utrecht] [UMCU]
Institut de Mathématiques de Bordeaux [IMB]
< Leer menos
University Medical Center [Utrecht] [UMCU]
Institut de Mathématiques de Bordeaux [IMB]
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en
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Este ítem está publicado en
IEEE International Symposium on Biomedical Imaging (ISBI), 2014-04-16, Beijing.
Resumen en inglés
Local drug delivery in oncology aims at depositing high doses of anticancer agents while limiting their toxic side effects. Biological barriers, such as cell plasma membranes, hinder their delivery and requires strategies ...Leer más >
Local drug delivery in oncology aims at depositing high doses of anticancer agents while limiting their toxic side effects. Biological barriers, such as cell plasma membranes, hinder their delivery and requires strategies to address this challenge. Previously [1], we demonstrated the feasibility to monitor in real-time, with dynamic fluorescence microscopy, the in-tracellular delivery of a hydrophilic model drug mediated by ultrasound (US), and to quantify the pharmacokinetic parameters derived from a two-compartment model. We evaluate here the impact of the photobleaching (PB) effect experimentally , and compute the PB-corrected uptake kinetics.< Leer menos
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