In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity
COUDIÈRE, Yves
Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
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Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
COUDIÈRE, Yves
Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
< Réduire
Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Langue
en
Communication dans un congrès
Ce document a été publié dans
LACM 2015 (2nd International Workshop on Latest Advances in Cardiac Modeling), 2015-03-12, German Heart Center, Munich. 2015-03-12
Résumé en anglais
Computational modeling and simulation is extensively used to investigate diseases in cardiac electrophysiological activity and also drug effects, side effects and interactions. Human embryonic stem cell-derived cardiomyocytes ...Lire la suite >
Computational modeling and simulation is extensively used to investigate diseases in cardiac electrophysiological activity and also drug effects, side effects and interactions. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been recently considered as a promising tool in regenerative medicine: their major role in repairing damaged tissue is due to pluripotency and ability to differentiate. These pluripotent cells are also used in early stages of drugs development. Pharmaceutical companies use the MultiElectrode Array (MEA) device in order to perform many in vitro experiments on hESC-CMs. The goal of our study is to derive a mathematical model and to simulate these in vitro experiments.< Réduire
Mots clés en anglais
MEA
hESC-CMs
field potential
drug modelling
Origine
Importé de halUnités de recherche