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In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity

hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorABBATE, Emanuela
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorZEMZEMI, Nejib
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
dc.contributor.authorCOUDIÈRE, Yves
hal.structure.identifierNumerical simulation of biological flows [REO]
dc.contributor.authorGERBEAU, Jean-Frédéric
dc.date.accessioned2024-04-04T03:17:36Z
dc.date.available2024-04-04T03:17:36Z
dc.date.created2015-03-12
dc.date.issued2015-03-12
dc.date.conference2015-03-12
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/194320
dc.description.abstractEnComputational modeling and simulation is extensively used to investigate diseases in cardiac electrophysiological activity and also drug effects, side effects and interactions. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been recently considered as a promising tool in regenerative medicine: their major role in repairing damaged tissue is due to pluripotency and ability to differentiate. These pluripotent cells are also used in early stages of drugs development. Pharmaceutical companies use the MultiElectrode Array (MEA) device in order to perform many in vitro experiments on hESC-CMs. The goal of our study is to derive a mathematical model and to simulate these in vitro experiments.
dc.language.isoen
dc.subject.enMEA
dc.subject.enhESC-CMs
dc.subject.enfield potential
dc.subject.endrug modelling
dc.title.enIn silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity
dc.typeCommunication dans un congrès
dc.subject.halMathématiques [math]
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicaments
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleLACM 2015 (2nd International Workshop on Latest Advances in Cardiac Modeling)
bordeaux.countryDE
bordeaux.conference.cityGerman Heart Center, Munich
bordeaux.peerReviewedoui
hal.identifierhal-01202019
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2015-03-13
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01202019v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2015-03-12&rft.au=ABBATE,%20Emanuela&ZEMZEMI,%20Nejib&COUDI%C3%88RE,%20Yves&GERBEAU,%20Jean-Fr%C3%A9d%C3%A9ric&rft.genre=unknown


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