GIDEL, Floriane; VOYER, Damien; POIGNARD, Clair

doi:10.1109/TMAG.2019.2952156

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GIDEL, Floriane
Modélisation Mathématique pour l'Oncologie [MONC]

VOYER, Damien
EIGSI La Rochelle [EIGSI ]
Modélisation Mathématique pour l'Oncologie [MONC]

POIGNARD, Clair
Modélisation Mathématique pour l'Oncologie [MONC]

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IEEE Transactions on Magnetics. 2020-01, vol. 56, n° 3

Institute of Electrical and Electronics Engineers

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The paper deals with two different approaches to model cell aggregates submitted to an electric stimulation, namely the equivalent circuit approach and the theoretical homogenization. For each approach, the effective impedance of the cell aggregate is given, enabling a comparison between the different models. Regarding the circuit approach, a variability in the electric parameters of the circuit in series is known to provide anomalous relaxation similar to a constant phase element model. For lognormal distribution of the parameters, a new link between the effective impedance and both arithmetic and geometric means is given. The second approach deals with the theoretical –but periodic– homogenization approach. The idea is to consider the sample as a periodic aggregate composed of a large number of cells. In each cell the electric potential is governed by the electroquasistatic model. The formal two-scale analysis leads to the so-called bidomain model, enabling a novel definition of the tissue impedance, generalizing the Maxwell-Garnett formula to cells with any geometrical configuration and without any dilution assumption. Interestingly, the microscale cell organization is shown to impact the effective impedance of the sample, linking the cell and the tissue properties< Réduire

Mots clés en anglais

Homogenization

Numerical Characterization of Cell Spheroids

Cell Networks

Electrical Modeling of Cell Aggregates

Multiscale Modeling

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In Silico Electrical Modeling of Cell Aggregates

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