Physiological changes may dominate the electrical properties of liver during reversible electroporation: Measurements and modelling
GARCIA-SANCHEZ, Tomas
Universitat Pompeu Fabra [Barcelona] [UPF]
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
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Universitat Pompeu Fabra [Barcelona] [UPF]
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
GARCIA-SANCHEZ, Tomas
Universitat Pompeu Fabra [Barcelona] [UPF]
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
Universitat Pompeu Fabra [Barcelona] [UPF]
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
MIR, Lluis
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
< Leer menos
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
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en
Article de revue
Este ítem está publicado en
Bioelectrochemistry. 2020-08, vol. 136, p. 107627
Elsevier
Resumen en inglés
This study presents electrical measurements (both conductivity during the pulses and impedance spec-troscopy before and after) performed in liver tissue of mice during electroporation with classical elec-trochemotherapy ...Leer más >
This study presents electrical measurements (both conductivity during the pulses and impedance spec-troscopy before and after) performed in liver tissue of mice during electroporation with classical elec-trochemotherapy conditions (8 pulses of 100 ms duration). A four-needle electrode arrangement inserted in the tissue was used for the measurements. The undesirable effects of the four-electrode geometry , notably concerning its sensitivity, were quantified and discussed showing how the electrode geometry chosen for the measurements can impact the results. Numerical modelling was applied to the information collected during the pulse, and to the impedance spectra acquired before and after the pulses sequence. Our results show that the numerical results were not consistent, suggesting that other collateral phenomena not considered in the model are at work during electroporation in vivo. We show how the modification in the volume of the intra and extra cellular media, likely caused by the vascular lock effect, could at least partially explain the recorded impedance evolution. In the present study we demonstrate the significant impact that physiological effects have on impedance changes following electropo-ration at the tissue scale and the potential need of introducing them into the numerical models. The code for the numerical model is publicly available at https://gitlab.inria.fr/poignard/4-electrode-system.< Leer menos
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