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Physiological changes may dominate the electrical properties of liver during reversible electroporation: Measurements and modelling

hal.structure.identifierUniversitat Pompeu Fabra [Barcelona] [UPF]
hal.structure.identifierAspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
dc.contributor.authorGARCIA-SANCHEZ, Tomas
hal.structure.identifierEIGSI La Rochelle [EIGSI ]
dc.contributor.authorVOYER, Damien
hal.structure.identifierModélisation Mathématique pour l'Oncologie [MONC]
dc.contributor.authorPOIGNARD, Clair
hal.structure.identifierAspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
dc.contributor.authorMIR, Lluis
dc.date.accessioned2024-04-04T02:50:24Z
dc.date.available2024-04-04T02:50:24Z
dc.date.issued2020-08
dc.identifier.issn1567-5394
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191908
dc.description.abstractEnThis study presents electrical measurements (both conductivity during the pulses and impedance spec-troscopy before and after) performed in liver tissue of mice during electroporation with classical elec-trochemotherapy conditions (8 pulses of 100 ms duration). A four-needle electrode arrangement inserted in the tissue was used for the measurements. The undesirable effects of the four-electrode geometry , notably concerning its sensitivity, were quantified and discussed showing how the electrode geometry chosen for the measurements can impact the results. Numerical modelling was applied to the information collected during the pulse, and to the impedance spectra acquired before and after the pulses sequence. Our results show that the numerical results were not consistent, suggesting that other collateral phenomena not considered in the model are at work during electroporation in vivo. We show how the modification in the volume of the intra and extra cellular media, likely caused by the vascular lock effect, could at least partially explain the recorded impedance evolution. In the present study we demonstrate the significant impact that physiological effects have on impedance changes following electropo-ration at the tissue scale and the potential need of introducing them into the numerical models. The code for the numerical model is publicly available at https://gitlab.inria.fr/poignard/4-electrode-system.
dc.language.isoen
dc.publisherElsevier
dc.title.enPhysiological changes may dominate the electrical properties of liver during reversible electroporation: Measurements and modelling
dc.typeArticle de revue
dc.identifier.doi10.1016/j.bioelechem.2020.107627
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale
dc.subject.halSciences du Vivant [q-bio]/Biotechnologies
bordeaux.journalBioelectrochemistry
bordeaux.page107627
bordeaux.volume136
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02914095
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02914095v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioelectrochemistry&rft.date=2020-08&rft.volume=136&rft.spage=107627&rft.epage=107627&rft.eissn=1567-5394&rft.issn=1567-5394&rft.au=GARCIA-SANCHEZ,%20Tomas&VOYER,%20Damien&POIGNARD,%20Clair&MIR,%20Lluis&rft.genre=article


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