BOUKENS, Bastiaan; POTSE, Mark; CORONEL, Ruben

doi:10.3390/ijms22041570

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BOUKENS, Bastiaan
Department of Experimental Cardiology, Amsterdam University Medical Center
Department of Medical Biology, Amsterdam University Medical Center

POTSE, Mark
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]

CORONEL, Ruben
Department of Experimental Cardiology, Amsterdam University Medical Center

Langue

Article de revue

Ce document a été publié dans

International Journal of Molecular Sciences. 2021-02-04, vol. 22, n° 4, p. 1570

MDPI

Résumé en anglais

Brugada syndrome and early repolarization syndrome are both classified as J-wave syndromes, with a similar mechanism of arrhythmogenesis and with the same basis for genesis of the characteristic electrocardiographic features. The Brugada syndrome is now considered a conduction disorder based on subtle structural abnormalities in the right ventricular outflow tract. Recent evidence suggests structural substrate in patients with the early repolarization syndrome as well. We propose a unifying mechanism based on these structural abnormalities explaining both arrhythmogenesis and the electrocardiographic changes. In addition, we speculate that, with increasing technical advances in imaging techniques and their spatial resolution, these syndromes will be reclassified as structural heart diseases or cardiomyopathies.< Réduire

Mots clés en anglais

Arrhythmias

Brugada syndrome

Early repolarization pattern

Fibrosis

Conduction

Repolarization

URI

https://oskar-bordeaux.fr/handle/20.500.12278/191639

DOI

http://dx.doi.org/10.3390/ijms22041570

Project ANR

L'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004

Origine

Importé de hal

Unités de recherche

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251