Fibrosis and Conduction Abnormalities as Basis for Overlap of Brugada Syndrome and Early Repolarization Syndrome
BOUKENS, Bastiaan
Department of Experimental Cardiology, Amsterdam University Medical Center
Department of Medical Biology, Amsterdam University Medical Center
Department of Experimental Cardiology, Amsterdam University Medical Center
Department of Medical Biology, Amsterdam University Medical Center
POTSE, Mark
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
BOUKENS, Bastiaan
Department of Experimental Cardiology, Amsterdam University Medical Center
Department of Medical Biology, Amsterdam University Medical Center
Department of Experimental Cardiology, Amsterdam University Medical Center
Department of Medical Biology, Amsterdam University Medical Center
POTSE, Mark
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
< Reduce
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
Language
en
Article de revue
This item was published in
International Journal of Molecular Sciences. 2021-02-04, vol. 22, n° 4, p. 1570
MDPI
English Abstract
Brugada syndrome and early repolarization syndrome are both classified as J-wave syndromes, with a similar mechanism of arrhythmogenesis and with the same basis for genesis of the characteristic electrocardiographic features. ...Read more >
Brugada syndrome and early repolarization syndrome are both classified as J-wave syndromes, with a similar mechanism of arrhythmogenesis and with the same basis for genesis of the characteristic electrocardiographic features. The Brugada syndrome is now considered a conduction disorder based on subtle structural abnormalities in the right ventricular outflow tract. Recent evidence suggests structural substrate in patients with the early repolarization syndrome as well. We propose a unifying mechanism based on these structural abnormalities explaining both arrhythmogenesis and the electrocardiographic changes. In addition, we speculate that, with increasing technical advances in imaging techniques and their spatial resolution, these syndromes will be reclassified as structural heart diseases or cardiomyopathies.Read less <
English Keywords
Arrhythmias
Brugada syndrome
Early repolarization pattern
Fibrosis
Conduction
Repolarization
ANR Project
L'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
Origin
Hal imported