SUTTER, O.; VOYER, D.; TASU, J.-P.; POIGNARD, C.

doi:10.1109/TBME.2023.3336193

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SUTTER, O.
Modélisation Mathématique pour l'Oncologie [MONC]

VOYER, D.
Modélisation Mathématique pour l'Oncologie [MONC]
EIGSI La Rochelle [EIGSI ]

TASU, J.-P.
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Laboratoire de Traitement de l'Information Medicale [LaTIM]

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IEEE Transactions on Biomedical Engineering. 2023p. 1-9

Institute of Electrical and Electronics Engineers

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In this paper we investigate the possibility of using needles, which the interventional radiologist inserts near a deep-seated tumor during an electroporation-based therapy, to characterize the electrical conductivity of patient's tissues. Specifically, we propose to exploit voltage/current measurements and imaging that are performed prior to the application of electroporation pulses. The approach is partly based on the concepts of electrical impedance tomography; however, imaging is used to build a specific geometric model and compensate for the lack of information resulting from the small number of electrodes available. 3D canonical and clinical examples, where a few electrodes surround a tumor, demonstrate the feasibility of this method: solving the inverse problem to estimate tissues conductivity converges in a few iterations. For a given error on the measurement, it is also possible to calculate the error on the estimated conductivities. The uncertainty error with clinical data is at best 5% for one of the tissues identified, due to the limitations of the clinical device used. Various improvements to clinical devices are discussed to make the conductivity estimation more accurate but also to extract more information.< Réduire

Mots clés en anglais

Electrical impedance tomography

Tumors

Conductivity Problem

Imaging

Needles

Electroporation

DC electrical conductivity

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How impedance measurements and imaging can be used to characterize the conductivity of tissues during the workflow of an electroporation-based therapy

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