LABARTHE, Simon; VIGMOND, Edward; COUDIÈRE, Yves; HENRY, Jacques; COCHET, Hubert; JAIS, Pierre

Métadonnées

Licence d’utilisation du document

LABARTHE, Simon
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]

VIGMOND, Edward
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]

COUDIÈRE, Yves
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]

Langue

Communication dans un congrès

Ce document a été publié dans

CINC - Computing in Cardiology 2013, 2013-09-22, Zaragoza. 2013-12-10, vol. 40, p. 1187-1190

Résumé en anglais

Atrial fibrosis is known to be a factor in the perpetu ation of atrial arrhythmia. Despite the thinness of atrial tissue, the fibrosis distribution may not be homogeneous through the entire thickness of the atria. This study aims to elucidate the respective influences of a transmural and a non-transmural distribution of fibrosis, described as a slow conduction zone, on the perpetuation of an arrhythmic episode, compared to a control situation. We used a bilayer monodomain representation of the atria that included transmural heterogeneities of fibre organisation. This model allowed long simulations for a sustainable computational load. We observed that when the fibrosis was transmural, the centre of the rotor was anchored in the slow conduction zone and was stable during a 10 seconds simulation, whereas the other simulations showed meandering rotors that disappeared after a few seconds. This study provided insight into the influence of transmural fibrosis on atrial arrhythmia perpetuation. In our model framework, only a transmural fibrosis distribution had a stabilizing effect on reentrant circuits. The bilayer model proved to be a good trade-off between accuracy and speed for observing the influence of transmural heterogeneities on atrial arrhythmia over long periods.< Réduire

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Influence of Transmural Slow-Conduction Zones on the Long- Time Behaviour Of Atrial Arrhythmia. A Numerical Study with a Human Bilayer Atrial Model

Langue

Ce document a été publié dans

Résumé en anglais

URI

Origine

Unités de recherche