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Influence of Transmural Slow-Conduction Zones on the Long- Time Behaviour Of Atrial Arrhythmia. A Numerical Study with a Human Bilayer Atrial Model

hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorLABARTHE, Simon
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorVIGMOND, Edward
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorCOUDIÈRE, Yves
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorHENRY, Jacques
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCOCHET, Hubert
hal.structure.identifierHôpital Haut-Lévêque
dc.contributor.authorJAIS, Pierre
dc.date.accessioned2024-04-04T02:20:35Z
dc.date.available2024-04-04T02:20:35Z
dc.date.issued2013-12-10
dc.date.conference2013-09-22
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/189503
dc.description.abstractEnAtrial fibrosis is known to be a factor in the perpetu ation of atrial arrhythmia. Despite the thinness of atrial tissue, the fibrosis distribution may not be homogeneous through the entire thickness of the atria. This study aims to elucidate the respective influences of a transmural and a non-transmural distribution of fibrosis, described as a slow conduction zone, on the perpetuation of an arrhythmic episode, compared to a control situation. We used a bilayer monodomain representation of the atria that included transmural heterogeneities of fibre organisation. This model allowed long simulations for a sustainable computational load. We observed that when the fibrosis was transmural, the centre of the rotor was anchored in the slow conduction zone and was stable during a 10 seconds simulation, whereas the other simulations showed meandering rotors that disappeared after a few seconds. This study provided insight into the influence of transmural fibrosis on atrial arrhythmia perpetuation. In our model framework, only a transmural fibrosis distribution had a stabilizing effect on reentrant circuits. The bilayer model proved to be a good trade-off between accuracy and speed for observing the influence of transmural heterogeneities on atrial arrhythmia over long periods.
dc.language.isoen
dc.title.enInfluence of Transmural Slow-Conduction Zones on the Long- Time Behaviour Of Atrial Arrhythmia. A Numerical Study with a Human Bilayer Atrial Model
dc.typeCommunication dans un congrès
dc.subject.halInformatique [cs]/Modélisation et simulation
bordeaux.page1187-1190
bordeaux.volume40
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.conference.titleCINC - Computing in Cardiology 2013
bordeaux.countryES
bordeaux.conference.cityZaragoza
bordeaux.peerReviewedoui
hal.identifierhal-00921262
hal.version1
hal.invitednon
hal.proceedingsoui
hal.conference.end2013-09-25
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00921262v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2013-12-10&rft.volume=40&rft.spage=1187-1190&rft.epage=1187-1190&rft.au=LABARTHE,%20Simon&VIGMOND,%20Edward&COUDI%C3%88RE,%20Yves&HENRY,%20Jacques&COCHET,%20Hubert&rft.genre=unknown


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