COUPÉ, Pierrick; PLANCHE, Vincent; MANSENCAL, Boris; KAMROUI, Reda A.; KOUBIYR, Ismail; MANJON, Jose V.; TOURDIAS, Thomas

doi:10.1002/hbm.26464

COUPÉ, Pierrick
Laboratoire Bordelais de Recherche en Informatique [LaBRI]

PLANCHE, Vincent
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]

MANSENCAL, Boris

Laboratoire Bordelais de Recherche en Informatique [LaBRI]

Langue

Article de revue

Ce document a été publié dans

Human Brain Mapping. 2023-03-14, vol. 44, n° 17, p. 5602-5611

Résumé en anglais

Atrophy related to multiple sclerosis (MS) has been found at the early stages of the disease. However, the archetype dynamic trajectories of the neurodegenerative process, even prior to clinical diagnosis, remain unknown. We modeled the volumetric trajectories of brain structures across the entire lifespan using 40,944 subjects (38,295 healthy controls and 2649 MS patients). Then, we estimated the chronological progression of MS by assessing the divergence of lifespan trajectories between normal brain charts and MS brain charts. Chronologically, the first affected structure was the thalamus, then the putamen and the pallidum (around 4 years later), followed by the ventral diencephalon (around 7 years after thalamus) and finally the brainstem (around 9 years after thalamus). To a lesser extent, the anterior cingulate gyrus, insular cortex, occipital pole, caudate and hippocampus were impacted. Finally, the precuneus and accumbens nuclei exhibited a limited atrophy pattern. Subcortical atrophy was more pronounced than cortical atrophy. The thalamus was the most impacted structure with a very early divergence in life. Our experiments showed that lifespan models of most impacted structures could be an important tool for future preclinical/prodromal prognosis and monitoring of MS. © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.< Réduire

Mots clés en anglais

Multiple sclerosis

MRI

Atrophy

Thalamus

Staging

Lifespan

URI

https://oskar-bordeaux.fr/handle/20.500.12278/189094

DOI

http://dx.doi.org/10.1002/hbm.26464

Project ANR

Apprentissage profond pour la volumétrie cérébrale : vers le BigData en neuroscience
Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003

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Lifespan neurodegeneration of the human brain in multiple sclerosis

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Résumé en anglais

Mots clés en anglais

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Licence d’utilisation du document

Lifespan neurodegeneration of the human brain in multiple sclerosis

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Project ANR

Unités de recherche