TERRAL, Geoffrey; HARRELL, Evan; LEPOUSEZ, Gabriel; WARDS, Yohan; HUANG, Dinghuang; DOLIQUE, Tiphaine; CASALI, Giulio; NISSANT, Antoine; LLEDO, Pierre-Marie; FERREIRA, Guillaume; MARSICANO, Giovanni; ROUX, Lisa

Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

HARRELL, Evan
Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS]

LEPOUSEZ, Gabriel

Langue

Article de revue

Ce document a été publié dans

Nature Communications. 2024-02-09, vol. 15, n° 1, p. 1230

Résumé en anglais

Sensory perception depends on interactions between external inputs transduced by peripheral sensory organs and internal network dynamics generated by central neuronal circuits. In the sensory cortex, desynchronized network states associate with high signal-to-noise ratio stimulus-evoked responses and heightened perception. Cannabinoid-type-1-receptors (CB1Rs) - which influence network coordination in the hippocampus - are present in anterior piriform cortex (aPC), a sensory paleocortex supporting olfactory perception. Yet, how CB1Rs shape aPC network activity and affect odor perception is unknown. Using pharmacological manipulations coupled with multi-electrode recordings or fiber photometry in the aPC of freely moving male mice, we show that systemic CB1R blockade as well as local drug infusion increases the amplitude of gamma oscillations in aPC, while simultaneously reducing the occurrence of synchronized population events involving aPC excitatory neurons. In animals exposed to odor sources, blockade of CB1Rs reduces correlation among aPC excitatory units and lowers behavioral olfactory detection thresholds. These results suggest that endogenous endocannabinoid signaling promotes synchronized population events and dampen gamma oscillations in the aPC which results in a reduced sensitivity to external sensory inputs.< Réduire

Mots clés en anglais

Mice

Male

Animals

Olfactory Perception

Piriform Cortex

Endocannabinoids

Smell

Odorants

Cannabinoids

Olfactory Pathways

Olfactory Bulb

URI

https://oskar-bordeaux.fr/handle/20.500.12278/188627

Project ANR

Développement d'une infrastructure française distribuée coordonnée

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Endogenous cannabinoids in the piriform cortex tune olfactory perception.

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Mots clés en anglais

URI

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Voir/Ouvrir

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Licence d’utilisation du document

Endogenous cannabinoids in the piriform cortex tune olfactory perception.

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

Project ANR

Unités de recherche