MARIANI, Yamuna; COVELO, Ana; RODRIGUES, Rui; JULIO-KALAJZIĆ, Francisca; PAGANO ZOTTOLA, Antonio; LAVANCO, Gianluca; FABRIZIO, Michela; GISQUET, Doriane; DRAGO, Filippo; CANNICH, Astrid; BAUFRETON, Jerome; MARSICANO, Giovanni; BELLOCCHIO, Luigi

doi:10.1016/j.cub.2023.09.075

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

COVELO, Ana
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

RODRIGUES, Rui
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Document de travail - Pré-publication

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Current Biology - CB. vol. 33, n° 22, p. 5011-5022

Résumé en anglais

Repeated exposure to psychostimulants, such as amphetamine, causes a long-lasting enhancement in the behavioral responses to the drug, called behavioral sensitization. 1 This phenomenon involves several neuronal systems and brain areas, among which the dorsal striatum plays a key role. 2 The endocannabinoid system (ECS) has been proposed to participate in this effect, but the neuronal basis of this interaction has not been investigated. 3 In the CNS, the ECS exerts its functions mainly acting through the cannabinoid type-1 (CB1) receptor, which is highly expressed at terminals of striatal medium spiny neurons (MSNs) belonging to both the direct and indirect pathways. 4 In this study, we show that, although striatal CB1 receptors are not involved in the acute response to amphetamine, the behavioral sensitization and related synaptic changes require the activation of CB1 receptors specifically located at striatopallidal MSNs (indirect pathway). These results highlight a new mechanism of psychostimulant sensitization, a phenomenon that plays a key role in the health-threatening effects of these drugs.< Réduire

Mots clés en anglais

CB(1) receptor

Psychostimulants

Sensitization

Striato-pallidal transmission

URI

https://oskar-bordeaux.fr/handle/20.500.12278/186564

DOI

http://dx.doi.org/10.1016/j.cub.2023.09.075

Projet Européen

Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes

Project ANR

Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043

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Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization

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Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization

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Résumé en anglais

Mots clés en anglais

URI

DOI

Projet Européen

Project ANR

Unités de recherche