Enterosignatures define common bacterial guilds in the human gut microbiome
FRIOUX, Clémence
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
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Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
FRIOUX, Clémence
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
GHASSEMI NEDJAD, Chabname
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
< Leer menos
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Idioma
en
Article de revue
Este ítem está publicado en
Cell Host & Microbe. 2023-06, vol. 31, n° 7, p. 1111
Resumen en inglés
The human gut microbiome composition is generally in a stable dynamic equilibrium, but it can deteriorate into dysbiotic states detrimental to host health. To disentangle the inherent complexity and capture the ecological ...Leer más >
The human gut microbiome composition is generally in a stable dynamic equilibrium, but it can deteriorate into dysbiotic states detrimental to host health. To disentangle the inherent complexity and capture the ecological spectrum of microbiome variability, we used 5,230 gut metagenomes to characterize signatures of bacteria commonly co-occurring, termed enterosignatures (ESs). We find five generalizable ESs dominated by either Bacteroides, Firmicutes, Prevotella, Bifidobacterium, or Escherichia. This model confirms key ecological characteristics known from previous enterotype concepts, while enabling the detection of gradual shifts in community structures.Temporal analysis implies that the Bacteroides-associated ES is “core” in the resilience of westernized gut microbiomes, while combinations with other ESs often complement the functional spectrum. The model reliably detects atypical gut microbiomes correlated with adverse host health conditions and/or the presence of pathobionts. ESs provide an interpretable and generic model that enables an intuitive characterization of gut microbiome composition in health and disease.< Leer menos
Palabras clave en inglés
metagenomics
human gut microbiome
non-negative matrix factorization
dysbiosis
enterosignatures
enterotypes
Proyecto europeo
erc-stg-948219
Orígen
Importado de HalCentros de investigación