FRIOUX, Clémence; ANSORGE, Rebecca; ÖZKURT, Ezgi; GHASSEMI NEDJAD, Chabname; FRITSCHER, Joachim; QUINCE, Christopher; WASZAK, Sebastian; HILDEBRAND, Falk

doi:10.1016/j.chom.2023.05.024

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FRIOUX, Clémence
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]

ANSORGE, Rebecca
Quadram Institute

ÖZKURT, Ezgi
Quadram Institute

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Article de revue

Ce document a été publié dans

Cell Host & Microbe. 2023-06, vol. 31, n° 7, p. 1111

Résumé en anglais

The human gut microbiome composition is generally in a stable dynamic equilibrium, but it can deteriorate into dysbiotic states detrimental to host health. To disentangle the inherent complexity and capture the ecological spectrum of microbiome variability, we used 5,230 gut metagenomes to characterize signatures of bacteria commonly co-occurring, termed enterosignatures (ESs). We find five generalizable ESs dominated by either Bacteroides, Firmicutes, Prevotella, Bifidobacterium, or Escherichia. This model confirms key ecological characteristics known from previous enterotype concepts, while enabling the detection of gradual shifts in community structures.Temporal analysis implies that the Bacteroides-associated ES is “core” in the resilience of westernized gut microbiomes, while combinations with other ESs often complement the functional spectrum. The model reliably detects atypical gut microbiomes correlated with adverse host health conditions and/or the presence of pathobionts. ESs provide an interpretable and generic model that enables an intuitive characterization of gut microbiome composition in health and disease.< Réduire

Mots clés en anglais

metagenomics

human gut microbiome

non-negative matrix factorization

dysbiosis

enterosignatures

enterotypes

DOI

http://dx.doi.org/10.1016/j.chom.2023.05.024

Projet Européen

erc-stg-948219

Origine

Importé de hal

Unités de recherche

BioGeCo (Biodiversité Gènes & Communautés) - UMR 1202