A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum
SHERMAN, David James
Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
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Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE]
Language
en
Article de revue
This item was published in
mBio. 2023-04-25, vol. 14, n° 2
American Society for Microbiology
English Abstract
M. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating ...Read more >
M. tuberculosis (Mtb) within the caseous core of necrotic granulomas and cavities is extremely drug tolerant and presents a significant hurdle to treatment success and relapse prevention. Many in vitro models of nonreplicating persistence have been developed to characterize the physiologic and metabolic adaptations of Mtb and identify compounds active against this treatment-recalcitrant population.Read less <
Origin
Hal imported