MÄNTYLÄ, Elina; KANN, Michael; VIHINEN-RANTA, Maija

KANN, Michael
Microbiologie Fondamentale et Pathogénicité [MFP]

VIHINEN-RANTA, Maija

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Article de revue

Ce document a été publié dans

Viruses. 2017-10-02, vol. 9, n° 10

Résumé en anglais

Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome. In recent years, our understanding of the multistep process of the capsid nuclear import has improved, and led to the discovery of unique viral nuclear entry strategies. Preceded by endosomal transport, endosomal escape and microtubule-mediated movement to the vicinity of the nuclear envelope, the protoparvoviruses interact with the nuclear pore complexes. The capsids are transported actively across the nuclear pore complexes using nuclear import receptors. The nuclear import is sometimes accompanied by structural changes in the nuclear envelope, and is completed by intranuclear disassembly of capsids and chromatinization of the viral genome. This review discusses the nuclear import strategies of protoparvoviruses and describes its dynamics comprising active and passive movement, and directed and diffusive motion of capsids in the molecularly crowded environment of the cell.< Réduire

Mots clés en anglais

Active Transport

Cell Nucleus

Animals

Capsid

Capsid Proteins

Cell Nucleus

Genome

Viral

Humans

Karyopherins

Mice

Nuclear Envelope

Nuclear Pore

Parvovirus

Virus Internalization

Virus Replication

URI

https://oskar-bordeaux.fr/handle/20.500.12278/184858

Unités de recherche

MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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Protoparvovirus Knocking at the Nuclear Door.

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Résumé en anglais

Mots clés en anglais

URI

Unités de recherche