BADRELDIN, Mostafa; SALAS-AMBROSIO, Pedro; GARANGER, Elisabeth; LECOMMANDOUX, Sébastien; HARRISSON, Simon; BONDUELLE, Colin

doi:10.1016/j.progpolymsci.2023.101752

BADRELDIN, Mostafa
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

SALAS-AMBROSIO, Pedro
University of California [Los Angeles] [UCLA]

GARANGER, Elisabeth

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Progress in Polymer Science. 2023-12-01, vol. 147, p. 101752

Résumé en anglais

In polymer science, thermoresponsiveness refers to macromolecular systems that display a marked and discontinuous change in their physical properties with temperature. Such smart polymers are the focus of increasing attention as they provide new solutions to many applications (e.g., drug delivery, nanotechnology, tissue engineering and biotechnology). This review focuses on amino acid based polymers, mainly synthetic polypeptides that are obtained by ring-opening polymerization. These include polymers based on natural amino acids, synthetic or modified amino acids and N-alkylated glycine derivatives. Based on what is known about the behavior of natural proteins in response to temperature variations, this review provides a comprehensive overview of the state of the art of thermosensitive polypeptides through a detailed description i) of the structure/thermoresponsiveness relationship, ii) of the mechanisms involved at the molecular level, iii) of their possible applications both in materials science and in biomedical applications.< Réduire

Mots clés en anglais

Thermosensitive polymers

LCST

Thermosensitive polypeptides

Thermosensitive proteins

URI

https://oskar-bordeaux.fr/handle/20.500.12278/184628

DOI

http://dx.doi.org/10.1016/j.progpolymsci.2023.101752

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Thermoresponsive polymers: From natural proteins to amino acid based polymer synthesis

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Résumé en anglais

Mots clés en anglais

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