VIVIEN, Juliette; EL AZRAOUI, Anass; LHERAUX, Cloé; LANORE, Frederic; AOUIZERATE, Bruno; HERRY, Cyril; HUMEAU, Yann; BIENVENU, Thomas C. M.

doi:10.3389/fncel.2023.1212202

VIVIEN, Juliette
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

EL AZRAOUI, Anass
Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

LHERAUX, Cloé
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Frontiers in Cellular Neuroscience. 2023-06-26, vol. 17

Résumé en anglais

Imbalance between excitation and inhibition in the cerebral cortex is one of the main theories in neuropsychiatric disorder pathophysiology. Cortical inhibition is finely regulated by a variety of highly specialized GABAergic interneuron types, which are thought to organize neural network activities. Among interneurons, axo-axonic cells are unique in making synapses with the axon initial segment of pyramidal neurons. Alterations of axo-axonic cells have been proposed to be implicated in disorders including epilepsy, schizophrenia and autism spectrum disorder. However, evidence for the alteration of axo-axonic cells in disease has only been examined in narrative reviews. By performing a systematic review of studies investigating axo-axonic cells and axo-axonic communication in epilepsy, schizophrenia and autism spectrum disorder, we outline convergent findings and discrepancies in the literature. Overall, the implication of axo-axonic cells in neuropsychiatric disorders might have been overstated. Additional work is needed to assess initial, mostly indirect findings, and to unravel how defects in axo-axonic cells translates to cortical dysregulation and, in turn, to pathological states.< Réduire

Mots clés en anglais

Autism

Chandelier cell

Epilepsy

Interneuron

Schizophrenia

URI

https://oskar-bordeaux.fr/handle/20.500.12278/183760

DOI

http://dx.doi.org/10.3389/fncel.2023.1212202

Project ANR

University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028

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Axo-axonic cells in neuropsychiatric disorders: a systematic review.

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Axo-axonic cells in neuropsychiatric disorders: a systematic review.

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Résumé en anglais

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DOI

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Unités de recherche