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Can haematological changes constitute a surrogate diagnostic parameter to detect schistosomiasis in migrants and travellers? A retrospective analysis
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EN
Article de revue
This item was published in
New Microbes and New Infections. 2023-06-01, vol. 53, p. 101136
English Abstract
Earlier studies found characteristic haematological changes in African patients with active schistosomiasis. If consistently present, full blood counts (FBC) may be helpful to diagnose schistosomiasis also in migrants and ...Read more >
Earlier studies found characteristic haematological changes in African patients with active schistosomiasis. If consistently present, full blood counts (FBC) may be helpful to diagnose schistosomiasis also in migrants and returning travellers. A retrospective patient record review was conducted on data from seven European travel clinics, comparing FBC of egg-positive travellers and migrants to reference values. Sub-analyses were performed for children, returned travellers, migrants and different species. Data analysis included 382 subjects (median age 21.0 years [range 2-73]). In returned travellers, decreases in means of haemoglobin particularly in females (β = -0.82 g/dL, = 0.005), MCV (β = -1.6 fL, = 0.009), basophils, neutrophils, lymphocytes and monocytes (β = -0.07, < 0.001; -0.57, = 0.012; -0.57, < 0.001 and -0.13 10/μL, < 0.001, respectively) were observed. As expected, eosinophils were increased (β = +0.45 10/μL, p < 0.001). In migrants, a similar FBC profile was observed, yet thrombocytes and leukocytes were significantly lower in migrants (β = -48 10/μL < 0.001 and β = -2.35 10/μL, < 0.001, respectively). Active egg-producing infections are associated with haematological alterations in returned travellers and migrants. However, these differences are discrete and seem to vary among disease stage and species. Therefore, the FBC is unsuitable as a surrogate diagnostic parameter to detect schistosomiasis.Read less <
English Keywords
Full blood count
Haematology
Migrants
Returned travellers
S. haematobium
S. mansoni
Schistosomiasis
Travel