PRADEU, Thomas; DAIGNAN-FORNIER, Bertrand; EWALD, Andrew; GERMAIN, Pierre-Luc; OKASHA, Samir; PLUTYNSKI, Anya; BENZEKRY, Sébastien; BERTOLASO, Marta; BISSELL, Mina; BROWN, Joel S; CHIN-YEE, Benjamin; CHIN-YEE, Ian; CLEVERS, Hans; COGNET, Laurent; DARRASON, Marie; FARGE, Emmanuel; FEUNTEUN, Jean; GALON, Jérôme; GIROUX, Elodie; GREEN, Sara; GROSS, Fridolin; JAULIN, Fanny; KNIGHT, Rob; LACONI, Ezio; LARMONIER, Nicolas; MALEY, Carlo; MANTOVANI, Alberto; MOREAU, Violaine; NASSOY, Pierre; RONDEAU, Elena; SANTAMARIA, David; SAWAI, Catherine M; SELUANOV, Andrei; SEPICH-POORE, Gregory D; SISIRAK, Vanja; SOLARY, Eric; YVONNET, Sarah; LAPLANE, Lucie

doi:10.1111/brv.12971

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

DAIGNAN-FORNIER, Bertrand
Institut de biochimie et génétique cellulaires [IBGC]

EWALD, Andrew

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Biological Reviews. 2023-05-08

Résumé en anglais

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/183542

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http://dx.doi.org/10.1111/brv.12971

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Philosophie, phylogénie et biologie des cellules souches - ANR-19-CE27-0027

Unités de recherche

ImmunoConcEpT - UMR 5164

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Reuniting philosophy and science to advance cancer research.

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Résumé en anglais

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