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Reuniting philosophy and science to advance cancer research.

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorPRADEU, Thomas
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorDAIGNAN-FORNIER, Bertrand
dc.contributor.authorEWALD, Andrew
dc.contributor.authorGERMAIN, Pierre-Luc
dc.contributor.authorOKASHA, Samir
dc.contributor.authorPLUTYNSKI, Anya
dc.contributor.authorBENZEKRY, Sébastien
dc.contributor.authorBERTOLASO, Marta
dc.contributor.authorBISSELL, Mina
dc.contributor.authorBROWN, Joel S
dc.contributor.authorCHIN-YEE, Benjamin
dc.contributor.authorCHIN-YEE, Ian
dc.contributor.authorCLEVERS, Hans
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorCOGNET, Laurent
dc.contributor.authorDARRASON, Marie
dc.contributor.authorFARGE, Emmanuel
dc.contributor.authorFEUNTEUN, Jean
dc.contributor.authorGALON, Jérôme
dc.contributor.authorGIROUX, Elodie
dc.contributor.authorGREEN, Sara
dc.contributor.authorGROSS, Fridolin
dc.contributor.authorJAULIN, Fanny
dc.contributor.authorKNIGHT, Rob
dc.contributor.authorLACONI, Ezio
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorLARMONIER, Nicolas
dc.contributor.authorMALEY, Carlo
dc.contributor.authorMANTOVANI, Alberto
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorMOREAU, Violaine
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorNASSOY, Pierre
dc.contributor.authorRONDEAU, Elena
dc.contributor.authorSANTAMARIA, David
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorSAWAI, Catherine M
dc.contributor.authorSELUANOV, Andrei
dc.contributor.authorSEPICH-POORE, Gregory D
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorSISIRAK, Vanja
dc.contributor.authorSOLARY, Eric
dc.contributor.authorYVONNET, Sarah
dc.contributor.authorLAPLANE, Lucie
dc.date.accessioned2023-08-30T07:40:03Z
dc.date.available2023-08-30T07:40:03Z
dc.date.issued2023-05-08
dc.identifier.issn1469-185Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183542
dc.description.abstractEnCancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.
dc.description.sponsorshipPhilosophie, phylogénie et biologie des cellules souches - ANR-19-CE27-0027en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enReuniting philosophy and science to advance cancer research.
dc.title.alternativeBiol Rev Camb Philos Socen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/brv.12971en_US
dc.subject.halSciences du Vivant [q-bio]/Canceren_US
dc.identifier.pubmed37157910en_US
bordeaux.journalBiological Reviewsen_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04190936
hal.version1
hal.date.transferred2023-08-30T07:40:19Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biological%20Reviews&rft.date=2023-05-08&rft.eissn=1469-185X&rft.issn=1469-185X&rft.au=PRADEU,%20Thomas&DAIGNAN-FORNIER,%20Bertrand&EWALD,%20Andrew&GERMAIN,%20Pierre-Luc&OKASHA,%20Samir&rft.genre=article


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