SCHOLLHAMMER, Romain; QUINTYN RANTY, Marie-Laure; DE CLERMONT-GALLERANDE, Henri; CAVELIER, Florine; VALVERDE, Ibai E; VIMONT, Delphine; HINDIE, Elif; MORGAT, Clement

doi:10.3390/cancers15082345

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

QUINTYN RANTY, Marie-Laure

DE CLERMONT-GALLERANDE, Henri

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

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Ce document a été publié dans

Cancers. 2023-04-18, vol. 15, n° 8

Résumé en anglais

The imaging of Prostate-Specific Membrane Antigen (PSMA) is now widely used at the initial staging of prostate cancers in patients with a high metastatic risk. However, its ability to detect low-grade tumor lesions is not optimal. First, we prospectively performed neurotensin receptor-1 (NTS) IHC in a series of patients receiving both [Ga]Ga-PSMA-617 and [Ga]Ga-RM2 before prostatectomy. In this series, PSMA and GRP-R IHC were also available (n = 16). Next, we aimed at confirming the PSMA/GRP-R/NTS expression profile by retrospective autoradiography (n = 46) using a specific radiopharmaceuticals study and also aimed to decipher the expression of less-investigated targets such as NTS, SST and CXCR4. In the IHC study, all samples with negative PSMA staining (two patients with ISUP 2 and one with ISUP 3) were strongly positive for NTS staining. No samples were negative for all three stains-for PSMA, GRP-R or NTS. In the autoradiography study, binding of [In]In-PSMA-617 was high in all ISUP groups. However, some samples did not bind or bound weakly to [In]In-PSMA-617 (9%). In these cases, binding of [n]In-JMV 6659 and [In]In-JMV 7488 towards NTS and NTS was high. Targeting PSMA and NTS/NTS could allow for the detection of all intraprostatic lesions.< Réduire

Mots clés en anglais

Prostate cancer

Neuropeptide

PSMA

GRP-R

NTS1

NTS2

Neurotensin

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https://oskar-bordeaux.fr/handle/20.500.12278/182850

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http://dx.doi.org/10.3390/cancers15082345

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Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287

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Theranostics of Primary Prostate Cancer: Beyond PSMA and GRP-R

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