Theranostics of Primary Prostate Cancer: Beyond PSMA and GRP-R
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | SCHOLLHAMMER, Romain | |
| dc.contributor.author | QUINTYN RANTY, Marie-Laure | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | DE CLERMONT-GALLERANDE, Henri | |
| dc.contributor.author | CAVELIER, Florine | |
| dc.contributor.author | VALVERDE, Ibai E | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | VIMONT, Delphine | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | HINDIE, Elif | |
| hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
| dc.contributor.author | MORGAT, Clement | |
| dc.date.accessioned | 2023-06-28T08:11:46Z | |
| dc.date.available | 2023-06-28T08:11:46Z | |
| dc.date.issued | 2023-04-18 | |
| dc.identifier.issn | 2072-6694 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182850 | |
| dc.description.abstractEn | The imaging of Prostate-Specific Membrane Antigen (PSMA) is now widely used at the initial staging of prostate cancers in patients with a high metastatic risk. However, its ability to detect low-grade tumor lesions is not optimal. First, we prospectively performed neurotensin receptor-1 (NTS) IHC in a series of patients receiving both [Ga]Ga-PSMA-617 and [Ga]Ga-RM2 before prostatectomy. In this series, PSMA and GRP-R IHC were also available (n = 16). Next, we aimed at confirming the PSMA/GRP-R/NTS expression profile by retrospective autoradiography (n = 46) using a specific radiopharmaceuticals study and also aimed to decipher the expression of less-investigated targets such as NTS, SST and CXCR4. In the IHC study, all samples with negative PSMA staining (two patients with ISUP 2 and one with ISUP 3) were strongly positive for NTS staining. No samples were negative for all three stains-for PSMA, GRP-R or NTS. In the autoradiography study, binding of [In]In-PSMA-617 was high in all ISUP groups. However, some samples did not bind or bound weakly to [In]In-PSMA-617 (9%). In these cases, binding of [n]In-JMV 6659 and [In]In-JMV 7488 towards NTS and NTS was high. Targeting PSMA and NTS/NTS could allow for the detection of all intraprostatic lesions. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Prostate cancer | |
| dc.subject.en | Neuropeptide | |
| dc.subject.en | PSMA | |
| dc.subject.en | GRP-R | |
| dc.subject.en | NTS1 | |
| dc.subject.en | NTS2 | |
| dc.subject.en | Neurotensin | |
| dc.title.en | Theranostics of Primary Prostate Cancer: Beyond PSMA and GRP-R | |
| dc.title.alternative | Cancers (Basel) | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/cancers15082345 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 37190273 | en_US |
| bordeaux.journal | Cancers | en_US |
| bordeaux.volume | 15 | en_US |
| bordeaux.hal.laboratories | Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | Imagerie multimodale translationnelle | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancers&rft.date=2023-04-18&rft.volume=15&rft.issue=8&rft.eissn=2072-6694&rft.issn=2072-6694&rft.au=SCHOLLHAMMER,%20Romain&QUINTYN%20RANTY,%20Marie-Laure&DE%20CLERMONT-GALLERANDE,%20Henri&CAVELIER,%20Florine&VALVERDE,%20Ibai%20E&rft.genre=article |
