LEVY, Yves; WIEDEMANN, Aurelie; HEJBLUM, Boris; DURAND, Melany; LEFEBVRE, Cecile; SURENAUD, Mathieu; LACABARATZ, Christine; PERREAU, Matthieu; FOUCAT, Emile; DECHENAUD, Marie; TISSERAND, Pascaline; BLENGIO, Fabiola; HIVERT, Benjamin; GAUTHIER, Marine; CERVANTES-GONZALEZ, Minerva; BACHELET, Delphine; LAOUENAN, Cedric; BOUADMA, Lila; TIMSIT, Jean-Francois; YAZDANPANAH, Yazdan; PANTALEO, Giuseppe; HOCINI, Hakim; THIEBAUT, Rodolphe

doi:10.1016/j.isci.2021.102711

Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]

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Article de revue

Ce document a été publié dans

iScience. 2021-07-23, vol. 24, n° 7, p. 102711

Résumé en anglais

The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care.< Réduire

Mots clés en anglais

Immunology

Virology

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182834

DOI

http://dx.doi.org/10.1016/j.isci.2021.102711

Project ANR

Initiative for the creation of a Vaccine Research Institute

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death