CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death
dc.rights.license | open | en_US |
dc.contributor.author | LEVY, Yves | |
dc.contributor.author | WIEDEMANN, Aurelie | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | HEJBLUM, Boris
ORCID: 0000-0003-0646-452X IDREF: 189970316 | |
dc.contributor.author | DURAND, Melany | |
dc.contributor.author | LEFEBVRE, Cecile | |
dc.contributor.author | SURENAUD, Mathieu | |
dc.contributor.author | LACABARATZ, Christine | |
dc.contributor.author | PERREAU, Matthieu | |
dc.contributor.author | FOUCAT, Emile | |
dc.contributor.author | DECHENAUD, Marie | |
dc.contributor.author | TISSERAND, Pascaline | |
dc.contributor.author | BLENGIO, Fabiola | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | HIVERT, Benjamin | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | GAUTHIER, Marine | |
dc.contributor.author | CERVANTES-GONZALEZ, Minerva | |
dc.contributor.author | BACHELET, Delphine | |
dc.contributor.author | LAOUENAN, Cedric | |
dc.contributor.author | BOUADMA, Lila | |
dc.contributor.author | TIMSIT, Jean-Francois | |
dc.contributor.author | YAZDANPANAH, Yazdan | |
dc.contributor.author | PANTALEO, Giuseppe | |
dc.contributor.author | HOCINI, Hakim | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | THIEBAUT, Rodolphe | |
dc.date.accessioned | 2023-06-26T14:27:27Z | |
dc.date.available | 2023-06-26T14:27:27Z | |
dc.date.issued | 2021-07-23 | |
dc.identifier.issn | 2589-0042 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182834 | |
dc.description.abstractEn | The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care. | |
dc.description.sponsorship | Initiative for the creation of a Vaccine Research Institute | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject.en | Immunology | |
dc.subject.en | Virology | |
dc.title.en | CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.isci.2021.102711 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 34127958 | en_US |
bordeaux.journal | iScience | en_US |
bordeaux.page | 102711 | en_US |
bordeaux.volume | 24 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 7 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | SISTM_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.export | false | |
dc.rights.cc | Pas de Licence CC | en_US |
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