MARCHESE, Letícia; NASCIMENTO, Janaina; DAMASCENO, Flávia; BRINGAUD, Frédéric; MICHELS, Paul; SILBER, Ariel

doi:10.3390/pathogens7020036

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Article de revue

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Pathogens. 2018, vol. 7, n° 2, p. 36

Resumen en inglés

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.< Leer menos

Palabras clave en inglés

amino acid metabolism

amino acid uptake

bioenergetics

stress management

autophagy

host-parasite interaction

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182819

DOI

http://dx.doi.org/10.3390/pathogens7020036

Proyecto ANR

Voies métaboliques glycosomales non glycolytiques: nouvelles fonctions pour le développement et la virulence des trypanosomes - ANR-15-CE15-0025
Alliance française contre les maladies parasitaires - ANR-11-LABX-0024

Centros de investigación

MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids