Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction
CIOFI, Philippe
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Langue
EN
Article de revue
Ce document a été publié dans
EMBO Journal. 2020-10-01, vol. 39, n° 19
Résumé en anglais
Hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH), the “master molecule” regulating reproduction and fertility, migrate from their birthplace in the nose to their destination using a system of guidance ...Lire la suite >
Hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH), the “master molecule” regulating reproduction and fertility, migrate from their birthplace in the nose to their destination using a system of guidance cues, which include the semaphorins and their receptors, the neuropilins and plexins, among others. Here, we show that selectively deleting neuropilin-1 in new GnRH neurons enhances their survival and migration, resulting in excess neurons in the hypothalamus and in their unusual accumulation in the accessory olfactory bulb, as well as an acceleration of mature patterns of activity. In female mice, these alterations result in early prepubertal weight gain, premature attraction to male odors, and precocious puberty. Our findings suggest that rather than being influenced by peripheral energy state, GnRH neurons themselves, through neuropilin–semaphorin signaling, might engineer the timing of puberty by regulating peripheral adiposity and behavioral switches, thus acting as a bridge between the reproductive and metabolic axes. © 2020 The Authors< Réduire
Mots clés en anglais
Chemotropic factors
Energy homeostasis
Hypothalamus
Puberty onset
Sexual behavior
Project ANR
La signalisation cellulaire par les sémaphorines dans le contrôle neuroendocrinien de la reproduction - ANR-14-CE12-0015
Vieillissement et démence: un rôle hormonal?
Vieillissement et démence: un rôle hormonal?
Unités de recherche