VANACKER, Charlotte; TROVA, Sara; SHRUTI, Sonal; CASONI, Filippo; MESSINA, Andrea; CROIZIER, Sophie; MALONE, Samuel; TERNIER, Gaetan; HANCHATE, Naresh Kumar; RASIKA, S.; BOURET, Sebastien G.; CIOFI, Philippe; GIACOBINI, Paolo; PREVOT, Vincent

doi:10.15252/embj.2020104633

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VANACKER, Charlotte
Lille Neurosciences & Cognition - U 1172 [LilNCog]

TROVA, Sara
Lille Neurosciences & Cognition - U 1172 [LilNCog]

SHRUTI, Sonal
Lille Neurosciences & Cognition - U 1172 [LilNCog]

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Article de revue

Este ítem está publicado en

EMBO Journal. 2020-10-01, vol. 39, n° 19

Resumen en inglés

Hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH), the “master molecule” regulating reproduction and fertility, migrate from their birthplace in the nose to their destination using a system of guidance cues, which include the semaphorins and their receptors, the neuropilins and plexins, among others. Here, we show that selectively deleting neuropilin-1 in new GnRH neurons enhances their survival and migration, resulting in excess neurons in the hypothalamus and in their unusual accumulation in the accessory olfactory bulb, as well as an acceleration of mature patterns of activity. In female mice, these alterations result in early prepubertal weight gain, premature attraction to male odors, and precocious puberty. Our findings suggest that rather than being influenced by peripheral energy state, GnRH neurons themselves, through neuropilin–semaphorin signaling, might engineer the timing of puberty by regulating peripheral adiposity and behavioral switches, thus acting as a bridge between the reproductive and metabolic axes. © 2020 The Authors< Leer menos

Palabras clave en inglés

Chemotropic factors

Energy homeostasis

Hypothalamus

Puberty onset

Sexual behavior

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182697

DOI

http://dx.doi.org/10.15252/embj.2020104633

Proyecto ANR

La signalisation cellulaire par les sémaphorines dans le contrôle neuroendocrinien de la reproduction - ANR-14-CE12-0015
Vieillissement et démence: un rôle hormonal?

Centros de investigación

Neurocentre Magendie - U1215