LEVY, Anna; EL-HAGE, Wissam; BENNABI, Djamila; ALLAUZE, Etienne; BOUVARD, Alexandra; CAMUS, Vincent; COURTET, Philippe; DOREY, Jean-Michel; ETAIN, Bruno; FOND, Guillaume; GENTY, Jean-Baptiste; HOLTZMANN, Jerome; HORN, Mathilde; LEBOYER, Marion; LLORCA, Pierre-Michel; MEYREL, Manon; MOLIERE, Fanny; NGUON, Anne-Sophie; PETRUCCI, Jean; REY, Romain; RICHIERI, Raphaelle; STEPHAN, Florian; VAIVA, Guillaume; WALTER, Michel; HAFFEN, Emmanuel; AOUIZERATE, Bruno; YRONDI, Antoine

doi:10.3389/fpsyt.2021.795666

LEVY, Anna
Fondation FondaMental [Créteil]

EL-HAGE, Wissam
Imaging, Brain & Neuropsychiatry [iBraiN]
Fondation FondaMental [Créteil]

BENNABI, Djamila
Fondation FondaMental [Créteil]
Laboratoires de neurosciences intégratives et cliniques (EA 481)

Langue

Article de revue

Ce document a été publié dans

Frontiers in Psychiatry. 2021, vol. 12

Résumé en anglais

Introduction: Treatment-resistant depression (TRD) is a disabling psychiatric condition characterized by the failure of two antidepressants (ADs). Since the occurrence of side effects (SEs) appears to be one of the main determinants of early discontinuation of pharmacological treatments contributing to a pseudo-resistance, the purpose of this study was to determine the parameters associated with the occurrence of SEs under ADs in a cohort of patients with TRD.Methods: An observational, cross-sectional, multicentre study was carried out using data from the French network of Expert Centers for TRD. For the 108 patients enrolled in the study, the statistical analyses focused on the overall occurrence and on the profile of the SEs (9 categories, 32 items).Results: SEs were influenced by age and sex and were positively associated with the intensity of anxious, depressive and suicidal symptoms, a history of childhood trauma (sexual abuse, emotional abuse and neglect), and negatively associated with self-esteem, and assessment of overall functioning.Conclusion: Using variables accessible in common practice, these results fall within the dynamic of a more tailored approach to medicine that could allow, through integrated pharmacological management, the continuation of antidepressant treatments, and therefore limit the risk of therapeutic failure.< Réduire

Mots clés en anglais

Expert centres

Treatment-resistant depression

Antidepressants

Side effects

Clinical severity

Childhood trauma

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182644

DOI

http://dx.doi.org/10.3389/fpsyt.2021.795666

Project ANR

Sorbonne Universités à Paris pour l'Enseignement et la Recherche

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Occurrence of Side Effects in Treatment-Resistant Depression: Role of Clinical, Socio-Demographic and Environmental Characteristics