KAUSS, Tina; ARPIN, Corinne; BIENTZ, Léa; VINH NGUYEN, Phouc; VIALET, Brune; BENIZRI, Sébastien; BARTHÉLÉMY, Philippe

doi:10.1038/s41598-020-58047-x

Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA]

ARPIN, Corinne

Microbiologie Fondamentale et Pathogénicité [MFP]

BIENTZ, Léa
Microbiologie Fondamentale et Pathogénicité [MFP]

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Article de revue

Ce document a été publié dans

Scientific Reports. 2020-01-23, vol. 10, n° 1, p. 1054

Résumé en anglais

Antibiotic resistance has become a major issue in public health especially for one of the most used antibiotics; the third-generation cephalosporins. One of the main resistance mechanisms in Enterobacteriaceae, is the production of Extended-Spectrum β-lactamases. Here, we demonstrated that the oligonucleotide therapy is an efficient approach to reduce the resistance of bacteria to antibiotic treatment. Lipid oligonucleotides (LONs) were proved to be efficient strategies in both delivering the oligonucleotide sequences in the prokaryotic cells and decreasing the Minimum Inhibitory Concentration of resistant bacteria to a third generation cephalosporin, the ceftriaxone. Accordingly, we demonstrated the strong antimicrobial potential of this LON strategy targeting the ß-lactamase activity on both clinical and laboratory strains. Our results support the concept that the self-delivery of oligonucleotide sequences via lipid conjugation may be extended to other antimicrobial drugs, which opens novel ways to struggle against the antibiotic resistance.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182404

DOI

http://dx.doi.org/10.1038/s41598-020-58047-x

Unités de recherche

MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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Lipid oligonucleotides as a new strategy for tackling the antibiotic resistance

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Résumé en anglais

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