GOMBEAU, K.; BONZOM, J.M.; CAVALIÉ, I.; CAMILLERI, V.; ORJOLLET, D.; DUBOURG, N.; BEAUGELIN-SEILLERS, K.; BOURDINEAUD, J.P.; LENGAGNE, Thierry; ARMANT, O.; RAVANAT, J.L.; ADAM-GUILLERMIN, C.

doi:10.1016/j.jenvrad.2020.106429

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GOMBEAU, K.
Institut de biochimie et génétique cellulaires [IBGC]

BONZOM, J.M.

CAVALIÉ, I.

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Ce document a été publié dans

Journal of Environmental Radioactivity. 2020-12, vol. 225, p. 106429

Résumé en anglais

The long-term consequences of the nuclear disaster at the Fukushima Daiichi Nuclear Power Plant (FDNPP) that occurred on March 2011, have been scarcely studied on wildlife. We sampled Japanese tree frogs (Dryophytes japonicus), in a 50-km area around the FDNPP to test for an increase of DNA damages and variation of DNA methylation level. The ambient dose rate ranged between 0.4 and 2.8 µGy h-1 and the total estimated dose rate absorbed by frogs ranged between 0.4 and 4.9 µGy h-1. Frogs from contaminated sites exhibited a dose dependent increase of global genomic DNA methylation level (5-mdC and 5-hmdC) and of mitochondrial DNA damages. Such DNA damages may indicate a genomic instability, which may induce physiological adaptations governed by DNA methylation changes. This study stresses the need for biological data combining targeted molecular methods and classic ecotoxicology, in order to better understand the impacts on wildlife of long term exposure to low ionizing radiation levels.< Réduire

Mots clés en anglais

Japanese tree frog-Dryophytes japonicus

Fukushima

DNA methylation

mitochondrial DNA damage

ionizing radiation