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dc.rights.licenseopenen_US
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorBERNAL, Kevin
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorTOUMA, Charbel
hal.structure.identifierInstitut National de l'Environnement Industriel et des Risques [INERIS]
dc.contributor.authorERRADHOUANI, Chedi
hal.structure.identifierCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas [CIBERDEM]
hal.structure.identifierInstitut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute [IDIBELL]
dc.contributor.authorBORONAT-BELDA, Talía
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorGAILLARD, Lucas
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorAL KASSIR, Sara
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorLE MENTEC, Helene
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorMARTIN-CHOULY, Corinne
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorLAGADIC-GOSSMANN, Dominique
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorPODECHARD, Normand
hal.structure.identifierInstitut de recherche en santé, environnement et travail [Irset]
dc.contributor.authorLANGOUET, Sophie
hal.structure.identifierInstitut National de l'Environnement Industriel et des Risques [INERIS]
dc.contributor.authorBRION, Francois
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorKNOLL-GELLIDA, Anja
hal.structure.identifierLaboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) [U1211 INSERM/MRGM]
dc.contributor.authorBABIN, Patrick
hal.structure.identifierMasaryk University [Brno] [MUNI]
dc.contributor.authorBABICA, Pavel
hal.structure.identifierMasaryk University [Brno] [MUNI]
dc.contributor.authorSOVADINOVA, Iva
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorANDREAU, Karine
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorBAROUKI, Robert
hal.structure.identifierInstitute of Biophysics of the Czech Academy of Sciences [IBP / CAS]
dc.contributor.authorVONDRACEK, Jan
hal.structure.identifierCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas [CIBERDEM]
hal.structure.identifierInstitut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute [IDIBELL]
dc.contributor.authorALONSO-MAGDALENA, Paloma
hal.structure.identifierUniversité Paris Cité [UPCité]
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorBLANC, Etienne
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorKIM, Min Ji
hal.structure.identifierToxicité environnementale, cibles thérapeutiques, signalisation cellulaire [T3S - UMR_S 1124]
dc.contributor.authorCOUMOUL, Xavier
dc.date.accessioned2023-05-26T08:12:09Z
dc.date.available2023-05-26T08:12:09Z
dc.date.issued2022-12-01
dc.identifier.issn1873-3468en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182343
dc.description.abstractEnThe prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs. With regard to these pathomechanisms, we will discuss the needs, and the stakes of evolving the testing and assessment of endocrine disruptors to improve the prevention and management of metabolic diseases that have become a global epidemic since the end of last century.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAppetite
dc.subject.enBisphenol
dc.subject.enDioxin
dc.subject.enInflammation
dc.subject.enInsulin resistance
dc.subject.enMicrobiota
dc.subject.enPerfluorinated compounds
dc.subject.enPhthalate
dc.subject.enTBT
dc.title.enCombinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.
dc.title.alternativeFEBS Letten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/1873-3468.14465en_US
dc.identifier.pubmed35957500en_US
bordeaux.journalFEBS Lettersen_US
bordeaux.page3107-3123en_US
bordeaux.volume596en_US
bordeaux.hal.laboratoriesMaladies Rares : Génétique et Métabolisme (MRGM) - UMR 1211en_US
bordeaux.issue24en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=FEBS%20Letters&rft.date=2022-12-01&rft.volume=596&rft.issue=24&rft.spage=3107-3123&rft.epage=3107-3123&rft.eissn=1873-3468&rft.issn=1873-3468&rft.au=BERNAL,%20Kevin&TOUMA,%20Charbel&ERRADHOUANI,%20Chedi&BORONAT-BELDA,%20Tal%C3%ADa&GAILLARD,%20Lucas&rft.genre=article


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