TREMBLAY, Marie-Eve; MADORE, Charlotte; BORDELEAU, Maude; TIAN, Li; VERKHRATSKY, Alexei

doi:10.3389/fncel.2020.592214

MADORE, Charlotte
Nutrition et Neurobiologie intégrée [NutriNeuro]

BORDELEAU, Maude

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Ce document a été publié dans

Frontiers in Cellular Neuroscience. 2020-11-11, vol. 14, p. 1-15

Résumé en anglais

SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 expressed by neurones and glial cells, including astrocytes and microglia. Systemic infection which accompanies severe cases of COVID-19 also triggers substantial increase in circulating levels of chemokines and interleukins that compromise the blood-brain barrier, enter the brain parenchyma and affect its defensive systems, astrocytes and microglia. Brain areas devoid of a blood-brain barrier such as the circumventricular organs are particularly vulnerable to circulating inflammatory mediators. The performance of astrocytes and microglia, as well as of immune cells required for brain health, is considered critical in defining the neurological damage and neurological outcome of COVID-19. In this review, we discuss the neurotropism of SARS-CoV-2, the implication of neuroinflammation, adaptive and innate immunity, autoimmunity, as well as astrocytic and microglial immune and homeostatic functions in the neurological and psychiatric aspects of COVID-19. The consequences of SARS-CoV-2 infection during ageing, in the presence of systemic comorbidities, and for the exposed pregnant mother and foetus are also covered.< Réduire

Mots clés en anglais

COVID-19

SARS-CoV-2

immunity

astrocyte

microglia

ageing

comorbidity

development

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182295

DOI

http://dx.doi.org/10.3389/fncel.2020.592214

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Neuropathobiology of COVID-19: the role for glia

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Résumé en anglais

Mots clés en anglais

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