TRINDADE, Sandra; DE NIZ, Mariana; COSTA-SEQUEIRA, Mariana; BIZARRA-REBELO, Tiago; BENTO, Fábio; DEJUNG, Mario; NARCISO, Marta Valido; LÓPEZ-ESCOBAR, Lara; FERREIRA, João; BUTTER, Falk; BRINGAUD, Frederic; GJINI, Erida; FIGUEIREDO, Luisa

doi:10.1038/s41467-022-34622-w

Langue

Article de revue

Ce document a été publié dans

Nature Communications. 2022, vol. 13, n° 1, p. 7548

Résumé en anglais

Abstract When Trypanosoma brucei parasites, the causative agent of sleeping sickness, colonize the adipose tissue, they rewire gene expression. Whether this adaptation affects population behavior and disease treatment remained unknown. By using a mathematical model, we estimate that the population of adipose tissue forms (ATFs) proliferates slower than blood parasites. Analysis of the ATFs proteome, measurement of protein synthesis and proliferation rates confirm that the ATFs divide on average every 12 h, instead of 6 h in the blood. Importantly, the population of ATFs is heterogeneous with parasites doubling times ranging between 5 h and 35 h. Slow-proliferating parasites remain capable of reverting to the fast proliferation profile in blood conditions. Intravital imaging shows that ATFs are refractory to drug treatment. We propose that in adipose tissue, a subpopulation of T. brucei parasites acquire a slow growing behavior, which contributes to disease chronicity and treatment failure.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182174

DOI

http://dx.doi.org/10.1038/s41467-022-34622-w

Project ANR

Alliance française contre les maladies parasitaires - ANR-11-LABX-0024
Interactions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomoses

Voir/Ouvrir

Métadonnées

Licence d’utilisation du document

Slow growing behavior in African trypanosomes during adipose tissue colonization

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Project ANR

Unités de recherche

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Slow growing behavior in African trypanosomes during adipose tissue colonization

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Project ANR

Unités de recherche