Liposome adhesion generates traction stress
VOITURIEZ, Raphael
Laboratoire de Physique Théorique de la Matière Condensée [LPTMC]
Laboratoire Jean PERRIN
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Laboratoire de Physique Théorique de la Matière Condensée [LPTMC]
Laboratoire Jean PERRIN
VOITURIEZ, Raphael
Laboratoire de Physique Théorique de la Matière Condensée [LPTMC]
Laboratoire Jean PERRIN
< Reduce
Laboratoire de Physique Théorique de la Matière Condensée [LPTMC]
Laboratoire Jean PERRIN
Language
en
Article de revue
This item was published in
Nature Physics. 2014-01-19, vol. 10, n° 2, p. 163-169
Nature Publishing Group
English Abstract
Mechanical forces generated by cells modulate global shape changes required for essential life processes, such as polarization, division and spreading. Although the contribution of the cytoskeleton to cellular force ...Read more >
Mechanical forces generated by cells modulate global shape changes required for essential life processes, such as polarization, division and spreading. Although the contribution of the cytoskeleton to cellular force generation is widely recognized, the role of the membrane is considered to be restricted to passively transmitting forces. Therefore, the mechanisms by which the membrane can directly contribute to cell tension are overlooked and poorly understood. To address this, we directly measure the stresses generated during liposome adhesion. We find that liposome spreading generates large traction stresses on compliant substrates. These stresses can be understood as the equilibration of internal, hydrostatic pressures generated by the enhanced membrane tension built up during adhesion. These results underscore the role of membranes in the generation of mechanical stresses on cellular length scales and that the modulation of hydrostatic pressure due to membrane tension and adhesion can be channelled to perform mechanical work on the environment.Read less <
English Keywords
MEMBRANE TENSION
SUBSTRATE STIFFNESS
LIPID-MEMBRANES
CELL-MEMBRANES
DYNAMICS
VESICLES
AREA
FORCE
PERMEABILITY
STRENGTH
Origin
Hal imported